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Combining Lewis acids with copper catalysis and highly reactive Grignard reagents allows fine tuning of the reactivity and selectivity of both inherently unreactive and highly reactive electrophilic substrates in asymmetric… Click to show full abstract
Combining Lewis acids with copper catalysis and highly reactive Grignard reagents allows fine tuning of the reactivity and selectivity of both inherently unreactive and highly reactive electrophilic substrates in asymmetric C-C bond forming reactions. In this review we will discuss various examples where the application of this strategy provides access to efficient catalytic processes for the synthesis of chiral molecules such as alcohols, amides and heteroarenes.
Keywords:
carbon;
copper;
forming reactions;
lewis acids;
bond forming
Journal Title: Chimia
Year Published: 2018
Link to full text (if available)
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Journal Title: Chimia
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!