LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Direct and Selective Modification of RNA - An Open Challenge in Nucleic Acid Chemistry.

Photo by vlisidis from unsplash

We present the state-of-the-art in direct RNA modification as well as the challenges that hold back further development of RNA mechanistic probes and medicines. Solid-phase synthesis has revolutionized the synthesis… Click to show full abstract

We present the state-of-the-art in direct RNA modification as well as the challenges that hold back further development of RNA mechanistic probes and medicines. Solid-phase synthesis has revolutionized the synthesis of short DNAs and RNAs. Many open questions in RNA biology are with large long-non-coding RNAs or mRNAs and there is also interest in developing these big RNAs as medicines. Techniques for direct modification will become more important in the coming years and we give a current snapshot of the field here, with a bias towards our own contributions.

Keywords: rna; chemistry; modification rna; selective modification; direct selective

Journal Title: Chimia
Year Published: 2018

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.