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4-Membered heterocycles are low molecular weight polar scaffolds with intriguing potential for drug discovery. Despite their unquestionable value, methods to access such heterocycles remain scant. Here, we describe the generation… Click to show full abstract
4-Membered heterocycles are low molecular weight polar scaffolds with intriguing potential for drug discovery. Despite their unquestionable value, methods to access such heterocycles remain scant. Here, we describe the generation of oxetane- and azetidine- benzylic carbocations as a general strategy to access valuable 3,3-disubstituted derivatives.
Keywords:
development synthesis;
synthesis disubstituted;
ring carbocations;
carbocations positive;
positive development;
membered ring
Journal Title: CHIMIA
Year Published: 2023
Link to full text (if available)
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Journal Title: CHIMIA
Year Published: 2023
Link to full text (if available)
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recommendations!