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OBJECTIVE Long non-coding RNAs (LcRNAs) is related to lung cancer progression. This study aimed at exploring lncRNA GHET1 in non-small cell lung cancer (NSCLC). PATIENTS AND METHODS RT-PCR was used to detect lncRNA GHET1 expression in lung cancer specimen and cancer-adjacent areas. Kaplan-Meier assay was applied to investigate the prognosis of the patients with lung cancer. RESULTS The expression of lncRNA GHET1 in lung cancer specimen was significantly higher than that in the cancer-adjacent tissues, which was related to the tumor size, differentiation degree of tumor cells, and lymph node metastasis of clinical specimens. Moreover, lncRNA GHET1 predicted a poor prognosis for the patients with lung cancer. CONCLUSIONS LncRNA GHET1 might be a biomarker and molecular target of NSCLC, providing a potential therapeutic target of NSCLC.