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OBJECTIVE This study aimed to explore the effect of long non-coding RNA (LncRNA) LncOGD-1006 to ischemic stroke and the possible mechanism. MATERIALS AND METHODS The primary brain microvascular endothelial cells… Click to show full abstract
OBJECTIVE This study aimed to explore the effect of long non-coding RNA (LncRNA) LncOGD-1006 to ischemic stroke and the possible mechanism. MATERIALS AND METHODS The primary brain microvascular endothelial cells (bEnd.3) of oxygen-glucose deprivation (OGD) was used as a mimic of ischemic stroke in vitro. RESULTS The results showed that LncOGD-1006 was upregulated in bEnd.3 after OGD-induced. CONCLUSIONS LncOGD-1006 might act as a ceRNA to inhibit apoptosis in bEnd.3 cells by targeting miR-184-5p/CAAP1 pathway.
Journal Title: European review for medical and pharmacological sciences
Year Published: 2020
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