"Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt"

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Both ERK1/2 and Akt kinases activate mTORC1, but only the former is bidirectionally regulated by the status of serine S1364 on TSC2 that confers input-selective mTORC1 amplification or attenuation. Click to show full abstract

Both ERK1/2 and Akt kinases activate mTORC1, but only the former is bidirectionally regulated by the status of serine S1364 on TSC2 that confers input-selective mTORC1 amplification or attenuation.

Keywords: tsc2; akt; single serine; mtorc1; erk1 akt

Journal Title: Life Science Alliance
Year Published: 2022

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