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SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress

Oxidative stress causes a rapid translocation of SIRT6 from the nucleus to the cytoplasm leading to nuclear SIRT6 depletion and results in RPE damage that is more severe in the… Click to show full abstract

Oxidative stress causes a rapid translocation of SIRT6 from the nucleus to the cytoplasm leading to nuclear SIRT6 depletion and results in RPE damage that is more severe in the central region in mice.

Keywords: stress; oxidative stress; nucleus protects; overexpression nucleus; sirt6 overexpression

Journal Title: Life Science Alliance
Year Published: 2023

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