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Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope

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The LINC complex tethers the cell nucleus to the cytoskeleton to regulate mechanical forces during cell migration, differentiation, and various diseases. We provide evidence for SUN2 disulfide bond rearrangement as… Click to show full abstract

The LINC complex tethers the cell nucleus to the cytoskeleton to regulate mechanical forces during cell migration, differentiation, and various diseases. We provide evidence for SUN2 disulfide bond rearrangement as a physiologically relevant structural modification that regulates LINC complex functions.

Keywords: disulfide bond; sun2 regulates; linc; bond sun2

Journal Title: Life Science Alliance
Year Published: 2023

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