LAUSR

Received: Revised: Accepted: Published online: June 05, 2017 October 25, 2017 December 21, 2017 January 20, 2018 The objective of this study was to find out the toxicity of sodium arsenite on hematology, serum biochemical constituents and kidney of Teddy bucks. The accumulation of arsenic in blood as well as tissues along its excretion in feces and urine was also measured. Vitamin E was also used to ameliorate the toxicity on these parameters. Adult twelve Teddy bucks were equally divided into three groups; A, B and C. The animals in group A was kept as control, while in groups B and C were fed with sodium arsenite 5 mg/kg and sodium arsenite 5 mg/kg +Vit E 200 mg/kg body weights respectively for twelve weeks. Body weights, blood and serum biochemical parameters were evaluated fortnightly in all the groups. Similarly, total arsenic accumulation in blood and excretion in urine and feces were measured after every two weeks. At the end of experiment, animals were slaughtered and visceral organs were processed for arsenic level and histopathologically studies. On analysis of data, it was proved that there was significant P<0.05 decrease in body weight, total protein, albumin and creatinine in arsenic treated animals. Whereas, total level of arsenic in blood and tissues was increased significantly in arsenic exposed animals. The results also revealed that vitamin E alleviated toxic effects of sodium arsenite on body weight, blood and serum biochemical constituents in restoration of normal values of these parameters. It was also proved that this vitamin increased the arsenic concentration in urine and feces. It was concluded that arsenic causes the toxicity and vitamin E scavenges this toxicity. ©2017 PVJ. All rights reserved