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Insulin Therapy and Cardiovascular Outcome Trials (Cvots): Any Harm, Anytime?

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The therapeutic management of diabetes may on its own increase the risk of cardiovascular (CV) risk markers – directly or indirectly – through their pharmacological actions (e.g. side effects as… Click to show full abstract

The therapeutic management of diabetes may on its own increase the risk of cardiovascular (CV) risk markers – directly or indirectly – through their pharmacological actions (e.g. side effects as hypoglycaemia), or some metabolic changes (e.g. weight-gain, increased BP, etc.). As these risks may not have been anticipated or immediately noticed during clinical trials, 1 post hoc analyses and epidemiological follow up of clinical trials have raised concerns about the CV safety of some drugs used in the management of diabetes.

Keywords: therapy cardiovascular; insulin therapy; cardiovascular outcome; outcome trials; trials cvots; cvots harm

Journal Title: Genetics and Molecular Research
Year Published: 2018

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