LAUSR

The current study was designed to demonstrate the protective impact of vitamin C against some fetal and neonatal congenital malformations and anti-inflammatory non-steriodal–induced hepatotoxicity in them of white rats ,this study was carried out in animal house of biology department in Education Faculty for Girls -Kufa university from 1/11/2019 to 15/3/2020, 24 white female rats with age ranged between (11-12) weeks and weights ranged between (230-240) kg, in adition to (24) white male rats with ages between (9-11) weeks for mating, the female and male rats were placed together for mating, after obtaining the required number of pregnant female rats, these pregnant rats were distributed to 4 groups , each group included 6 pregnant rats ,the group1 was treated with normal saline solution and was the control group, group2 was treated with indomethacin drug with a concentration of 8.40 mg / kg of body weight, while group 3,4 were treated with vitamin C with a concentration of 85 mg /kg of body weight and vitaminC with a concentration of 85 mg / kg of body weight + indomethacin drug with a concentration of 8.40 mg / kg of body weight respectively, pregnant female rats in all groups were treated orally from the first day of pregnancy, 3 pregnant rats were dissected during 20 days of pregnancy, while the remaining 3 pregnant rats were left to after birth of each group. The results of the this study pointed to that a significant decrease (P