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Various types of titanium base alloys are utilized as implant materials and as minis crews in orthodontics. The purpose of the current study is to enhancing titanium-based alloys with the additions of Cobalt in different percentage (5%, 10%, and 15%) to enhance primary osteoblast attachment and implant tissue incorporation. the reaction between human MG63 osteoblast-like cells and titanium – cobalt alloy face is substantial in biomaterials and tissue engineering field. The major target was to estimate the proteomic response of MG63 osteoblast-like cells in various cobalt percentages. The samples with and without cobalt addition was produced by using powder technology in order to get an acceptable initial surface roughness. Also sample characterizations includes (scanning electron microscopy (SEM), X-ray diffraction (XRD), vitro test (Biocompatibility MTT assay with MG-63 Cells). Results obtained from XRD and microstructure observations, sample without cobalt addition refer to an alloy with single I± phase, while after the additions of cobalt in different percentage (5%, 10%, 15%) the samples consist of two I±-Ti and intermetallic compound Ti2Co and the amount of Ti2Co phase slightly increase with increasing cobalt content. From MTT assays Proliferation and cells attachment of MG63 were cultured after 2 days Cells grown for the pure titanium alloys possess finer and circular confines compared with the grown cells at (titanium – cobalt) alloys with all cobalt percentages. Rising cobalt percentage makes the MG63 cell sharper and enlarges which means cobalt aid to enhancing both cell proliferation and growth. Cytotoxicity Cell Viability results was kept, exhibition no kind of attack caused by titanium or cobalt materials, The feature, of cobalt additions, in contrast to commercial pure titanium alloys, is the presence of active and non- cytotoxic compound (Ti2Co) which presents several attractive features, make the surface more attractive to the bone .   How to Cite this Article Pubmed Style Fatimah J. Al-Hasani. Effect of Cobalt Addition on the Cytotoxicity and Cell Attachment of Titanium Alloys. SRP. 2020; 11(5): 804-813. doi:10.31838/srp.2020.5.119 Web Style Fatimah J. Al-Hasani. Effect of Cobalt Addition on the Cytotoxicity and Cell Attachment of Titanium Alloys. http://www.sysrevpharm.org/?mno=131488 [Access: March 30, 2021]. doi:10.31838/srp.2020.5.119 AMA (American Medical Association) Style Fatimah J. Al-Hasani. Effect of Cobalt Addition on the Cytotoxicity and Cell Attachment of Titanium Alloys. SRP. 2020; 11(5): 804-813. doi:10.31838/srp.2020.5.119 Vancouver/ICMJE Style Fatimah J. Al-Hasani. Effect of Cobalt Addition on the Cytotoxicity and Cell Attachment of Titanium Alloys. SRP. (2020), [cited March 30, 2021]; 11(5): 804-813. doi:10.31838/srp.2020.5.119 Harvard Style Fatimah J. Al-Hasani (2020) Effect of Cobalt Addition on the Cytotoxicity and Cell Attachment of Titanium Alloys. SRP, 11 (5), 804-813. doi:10.31838/srp.2020.5.119 Turabian Style Fatimah J. Al-Hasani. 2020. Effect of Cobalt Addition on the Cytotoxicity and Cell Attachment of Titanium Alloys. Systematic Reviews in Pharmacy, 11 (5), 804-813. doi:10.31838/srp.2020.5.119 Chicago Style Fatimah J. Al-Hasani. "Effect of Cobalt Addition on the Cytotoxicity and Cell Attachment of Titanium Alloys." Systematic Reviews in Pharmacy 11 (2020), 804-813. doi:10.31838/srp.2020.5.119 MLA (The Modern Language Association) Style Fatimah J. Al-Hasani. "Effect of Cobalt Addition on the Cytotoxicity and Cell Attachment of Titanium Alloys." Systematic Reviews in Pharmacy 11.5 (2020), 804-813. Print. doi:10.31838/srp.2020.5.119 APA (American Psychological Association) Style Fatimah J. Al-Hasani (2020) Effect of Cobalt Addition on the Cytotoxicity and Cell Attachment of Titanium Alloys. Systematic Reviews in Pharmacy, 11 (5), 804-813. doi:10.31838/srp.2020.5.119