LAUSR

Background: Limitations of antimalarial chemotherapy demonstrate the importance of the discovery of new drugs. Indonesia has a high diversity of plants and some have been demonstrated to have activity as an antimalarial. Fibraurea tinctoria Lour (FT) stem are widely found in East Kalimantan. Secondary metabolites i.e. alkaloids, flavonoids, polyphenols and terpenoids/steroids were found from the phytochemical screening of ethanol extract of yellow root stem FT. Objective: To determine in vivo antimalarial effect of yellow root stem FT against Plasmodium berghei. Methods: Yellow root stem FT was extracted with methanol. Mice were inoculated with Plasmodium berghei ANKA which injected intraperitoneally. Parasitemia degree was quantitated for 5 days. Results: There were significant difference found at therapy group treated with 10 mg/g BW extract combined with artemisinin, 1 mg/b BW extract combined with artemisinin and only artemisinin against the reduction degree of parasitaemia at p < 0.05. Conclusion: Therapy group under treatment of methanol extract of yellow root stem FT combined with artemisinin was proven to have effect on in vivo antimalarial activity.