Photo from wikipedia
A series of novel 2-(3,5-disubstituted isoxazolyl)-1,5-benzodiazepines and 2,4-bis-(3,5-disubstituted isoxazolyl)-1,5-benzodiazepine derivatives have been designed and synthesised by employing an alkyne/nitrile oxide cycloaddition ‘click’ type chemistry protocol. The structures of the compounds… Click to show full abstract
A series of novel 2-(3,5-disubstituted isoxazolyl)-1,5-benzodiazepines and 2,4-bis-(3,5-disubstituted isoxazolyl)-1,5-benzodiazepine derivatives have been designed and synthesised by employing an alkyne/nitrile oxide cycloaddition ‘click’ type chemistry protocol. The structures of the compounds were determined on the basis of 1H, 13C and 2D-NMR techniques and by HRMS analysis. These hybrid molecules exhibit moderate to significant antimicrobial and anti-tyrosinase activities.
Journal Title: Journal of Chemical Research
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!