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A new practical synthetic approach produced clinical drug candidate YT-14, improving the overall yield from 1.3% to 13.8%. Compared with the previous route, the new route is two steps shorter… Click to show full abstract
A new practical synthetic approach produced clinical drug candidate YT-14, improving the overall yield from 1.3% to 13.8%. Compared with the previous route, the new route is two steps shorter and all of the steps involve purifications without column chromatography. The advantages of this procedure include simple operating conditions and higher yields.
Keywords:
improved synthesis;
potent antibiotic;
antibiotic multidrug;
synthesis potent;
resistant strains;
multidrug resistant
Journal Title: Journal of Chemical Research
Year Published: 2018
Link to full text (if available)
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Journal Title: Journal of Chemical Research
Year Published: 2018
Link to full text (if available)
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recommendations!