LAUSR

Among the most promising unconventional targets for the development of new antimicrobial drugs is bacterial adherence and biofilm formation. This study is focused on the evaluation of a series of 2(3-pyridyl)-thiazolyl-1,3,4-oxadiazolines as bacterial biofilm inhibitors against a panel of Gram-positive bacterial strains. Some of these compounds showed interesting activity against biofilm formation of the Staphylococcus aureus strain. A preliminary study of the mechanism of action was carried out by a molecular docking assay between the compounds and the Sortase A enzyme. The connection between the docking results obtained and the anti-biofilm activity suggested that the tested compounds could have as potential mechanism of action the inhibition of Sortase A.