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Acridines belong to one of the most frequently studied class of compounds due to their numerous physico-chemical properties and their biological action. Thus, the use of acridines as antitumor, antibacterial,… Click to show full abstract
Acridines belong to one of the most frequently studied class of compounds due to their numerous physico-chemical properties and their biological action. Thus, the use of acridines as antitumor, antibacterial, antiviral, antimalarial and antinociceptive agents is known. Antitumour action is due to their ability to interfere with the structure of deoxyribonucleic acid (DNA), thereby disrupting its normal functioning. Electrochemical and spectral behaviour of the four compounds were investigated showing that only one N-oxyde acridine has the ability to intercalate into the single strand DNA (ssDNA). The binding constant was computed using H-NMR.
Journal Title: Farmacia
Year Published: 2018
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