LAUSR

Patients-reported outcomes can be used to measure health concepts that cover the full spectrum of human functioning. The objective of this study was to develop and validate a tool that could be used in assessment the adherence patients with chronic obstructive pulmonary disease (COPD). In the second part of the questionnaire we used EQ-5D-5L. COPD is characterized by progressive limitation of the respiratory flow which is not totally reversible. Pharmacological therapy is the basis for COPD treatment and includes inhaled bronchodilators such as β2 adrenergic agonists (e.g. olodaterol) and anticholinergic agents (e.g. tiotropium). Being a new treatment on the reimbursement list in Romania, the treatment with a fixed dose combination of olodaterol and tiotropium was one of the inclusion criteria of patients with COPD in this study. The tool has good measurement properties and provides a valid and reliable measure of COPD-specific adherence.