An antipsychotic drug containing risperidone can be analysed by liquid chromatographic techniques (LC) using UV-visible and fluorescence detectors. However, all developed methods based on LC are expensive, time consuming due… Click to show full abstract
An antipsychotic drug containing risperidone can be analysed by liquid chromatographic techniques (LC) using UV-visible and fluorescence detectors. However, all developed methods based on LC are expensive, time consuming due to pre-and post-column reaction, and also not very sensitive. The preparation of micro-sized composite risperidone-sensitive sensors and their suitability as detector in a flow-injection analysis system is described. A risperidone-sensitive sensor membrane was prepared by coating a composite cocktail on the surface of the contact transducer in solid state. The composition ratio percentage for the best performance was obtained with 2.5% (w/w) active ingredient (ionophore), 67% (w/w) plasticizer, 30% (w/w) PVC, and 0.5% sodium tetraphenyl borate. The potentiometric performances of risperidone-selective sensor (selectivity constant, liner domain, detection limit, response time, pH working domain, repeatability, lifetime, and time dependent potential decay) were determined using computer controlled measurement systems in static conditions.
               
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