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ANXIOLYTIC AND ANTIDEPRESSANT EFFECTS OF MATRICARIA CHAMOMILLA HYDROALCOHOLIC EXTRACT IN A RAT MODEL OF SCOPOLAMINE

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In the present study, we investigated the effects of the Matricaria chamomilla (chamomile) hydroalcoholic extract on anxiety and depression using a scopolamine rat model. Behavioural procedures for anxiety and depression… Click to show full abstract

In the present study, we investigated the effects of the Matricaria chamomilla (chamomile) hydroalcoholic extract on anxiety and depression using a scopolamine rat model. Behavioural procedures for anxiety and depression were assessed in rats using elevated plus maze and forced swimming tests. The chamomile extract (25 and 75 mg/kg b.w.) was given intraperitoneally once daily for 21 days, and scopolamine (0.7 mg/kg b.w.) was injected 30 minutes before the behavioural tests to induce anxiety and depression. The extract efficacy was matched by those elicited by diazepam (1.5 mg/kg b.w.) and tramadol (10 mg/kg b.w.) for anxiolytic and antidepressant studies. Our results demonstrated that the extract abolishes scopolamineinduced increasing of anxiety and depressive-like responses and exhibited therapeutic benefits for the management of psychological ailments.

Keywords: matricaria chamomilla; effects matricaria; rat model; hydroalcoholic extract; anxiolytic antidepressant

Journal Title: FARMACIA
Year Published: 2019

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