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A series of diclofenac hydrazones was synthesized and the structure of the compounds was proved using different spectral methods such as infrared (IR), nuclear magnetic resonance (H-NMR) and high resolution… Click to show full abstract
A series of diclofenac hydrazones was synthesized and the structure of the compounds was proved using different spectral methods such as infrared (IR), nuclear magnetic resonance (H-NMR) and high resolution mass spectroscopy (HR-MS). The biological evaluation, focused on in vitro antioxidant effects using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2’azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) free radicals scavenging assays was also performed. An improved antioxidant effect of the synthesized compounds compared to diclofenac was observed.
Journal Title: Farmacia
Year Published: 2020
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