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Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19

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We report in vivo selection of a severe acute respiratory syndrome coronavirus 2 spike mutation (Q493R) conferring simultaneous resistance to bamlanivimab and etesivimab. This mutation was isolated from a patient… Click to show full abstract

We report in vivo selection of a severe acute respiratory syndrome coronavirus 2 spike mutation (Q493R) conferring simultaneous resistance to bamlanivimab and etesivimab. This mutation was isolated from a patient who had coronavirus disease and was treated with these drugs.

Keywords: emergence sars; mutation q493r; cov spike; spike protein; sars cov; mutation

Journal Title: Emerging Infectious Diseases
Year Published: 2021

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