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Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections

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To determine neutralizing activity against the severe acute respiratory syndrome coronavirus 2 ancestral strain and 4 variants of concern, we tested serum from 30 persons with breakthrough infection after 2-dose… Click to show full abstract

To determine neutralizing activity against the severe acute respiratory syndrome coronavirus 2 ancestral strain and 4 variants of concern, we tested serum from 30 persons with breakthrough infection after 2-dose vaccination. Cross-variant neutralizing activity was comparable to that after 3-dose vaccination. Shorter intervals between vaccination and breakthrough infection correlated with lower neutralizing titers.

Keywords: neutralizing serum; cross variant; serum activity; activity; variant neutralizing

Journal Title: Emerging Infectious Diseases
Year Published: 2022

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