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Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates

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The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and… Click to show full abstract

The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas. We recommend using PCR or genomic assays to detect pCD-METRO in metronidazole-resistant C. difficile.

Keywords: clostridioides difficile; metronidazole resistant; pcd metro; sequence based

Journal Title: Emerging Infectious Diseases
Year Published: 2022

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