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Powassan Virus Infection Detected by Metagenomic Next-Generation Sequencing, Ohio, USA

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We describe a 4-year-old male patient in Ohio, USA, who had encephalitis caused by Powassan virus lineage 2. Virus was detected by using metagenomic next-generation sequencing and confirmed with IgM… Click to show full abstract

We describe a 4-year-old male patient in Ohio, USA, who had encephalitis caused by Powassan virus lineage 2. Virus was detected by using metagenomic next-generation sequencing and confirmed with IgM and plaque reduction neutralization assays. Clinicians should recognize changing epidemiology of tickborne viruses to enhance encephalitis diagnosis and management.

Keywords: powassan virus; next generation; metagenomic next; ohio usa; generation sequencing

Journal Title: Emerging Infectious Diseases
Year Published: 2023

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