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Adjuvant drug-assisted bone healing: Part III - Further strategies for local and systemic modulation.

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In this third in a series of reviews on adjuvant drug-assisted bone healing, further possibilities of influencing the healing process are discussed. Local and systemic modulation of bone metabolism is… Click to show full abstract

In this third in a series of reviews on adjuvant drug-assisted bone healing, further possibilities of influencing the healing process are discussed. Local and systemic modulation of bone metabolism is considered during use of a number of drugs with completely different indications, which are characterized by a pleiotropic spectrum of action. These include drugs used to treat lipid disorders (HMG-CoA reductase inhibitors), hypertension (ACE inhibitors), osteoporosis (bisphosphonates), cancer (proteasome inhibitors) and others. Possibilities of their application in the support of bone healing arediscussed.

Keywords: assisted bone; adjuvant drug; local systemic; bone healing; bone; drug assisted

Journal Title: Clinical hemorheology and microcirculation
Year Published: 2019

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