LAUSR

BACKGROUND: In endoscopic photoacoustic tomography (EPAT), the photoacoustically induced ultrasonic wave reflects at tissue boundaries due to the acoustic inhomogeneity of the imaged tissue, resulting in reflection artifacts (RAs) in the reconstructed images. OBJECTIVE: To suppress RAs in EPAT image reconstruction for improving the image quality. METHODS: A method was presented to render the cross-sectional images of the optical absorption with reduced RAs from acoustic measurements. The ideal photoacoustic signal was recovered from acoustic signals collected by the detector through solving a least square problem. Then, high-quality images of the optical absorption distribution were reconstructed from the ideal signal. RESULTS: The results demonstrated the improvement in the quality of the images rendered by this method in comparison with the conventional back-projection (BP) reconstructions. Compared with the short lag spatial coherence (SLSC) method, the peak signal-to-noise ratio (PSNR), normalized mean square absolute distance (NMSAD), and structural similarity (SSIM) were improved by up to 8%, 20%, and 5%, respectively. CONCLUSIONS: This method was capable of rendering images displaying the complex tissue types with reduced RAs and lower computational burden in comparison with previously developed methods.