LAUSR

BACKGROUND Low-dose computed tomography (LDCT) is an effective method for reducing radiation exposure. However, reducing radiation dose leads to considerable noise in the reconstructed image that can affect doctor's judgment. OBJECTIVE To solve this problem, this study proposes a local total variation and improved wavelet residual convolutional neural network (LTV-WRCNN) denoising model. METHODS The model first introduces local total variation (LTV) to decompose the LDCT image into cartoon and texture image. Next, the texture image is filtered using the non-local mean (NLM). Then, the cartoon image is added to the filtered texture image to obtain the preprocessing image. Finally, the pre-processed image is fed into the improved wavelet residual neural network (WRCNN) to obtain an improved image. Additionally, we also introduce a compound loss in wavelet domain that combines mean squared error loss and directional regularization loss to separate the structural details from noise more thoroughly. RESULTS Compared with state-of-the-art methods, the peak-signal-to-noise ratio (PSNR) value and the structure similarity (SSIM) value of the processed CT images using the new proposed model are 33.4229 dB and 0.9158. Study also shows that applying new model obtains better results visually and numerically, especially in terms of the preservation of structural details. CONCLUSIONS The proposed new model is feasible and effective in improving the quality of LDCT images.