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BACKGROUND Lung cancer has the second highest cancer mortality rate in the world today. Although lung cancer screening using CT images is a common way for early lung cancer detection, accurately detecting lung nodules remains a challenged issue in clinical practice. OBJECTIVE This study aims to develop a new weighted bidirectional recursive pyramid algorithm to address the problems of small size of lung nodules, large proportion of background region, and complex lung structures in lung nodule detection of CT images. METHODS First, the weighted bidirectional recursive feature pyramid network (BiPRN) is proposed, which can increase the ability of network model to extract feature information and achieve multi-scale fusion information. Second, a CBAM_CSPDarknet53 structure is developed to incorporate an attention mechanism as a feature extraction module, which can aggregate both spatial information and channel information of the feature map. Third, the weighted BiRPN and CBAM_CSPDarknet53 are applied to the YOLOvX model for lung nodule detection experiments, named BiRPN-YOLOvX, where YOLOvX represents different versions of YOLO. To verify the effectiveness of our weighted BiRPN and CBAM_ CSPDarknet53 algorithm, they are fused with different models of YOLOv3, YOLOv4 and YOLOv5, and extensive experiments are carried out using the publicly available lung nodule datasets LUNA16 and LIDC-IDRI. The training set of LUNA16 contains 949 images, and the validation and testing sets each contain 118 images. There are 1987, 248 and 248 images in LIDC-IDRI's training, validation and testing sets, respectively. RESULTS The sensitivity of lung nodule detection using BiRPN-YOLOv5 reaches 98.7% on LUNA16 and 96.2% on LIDC-IDRI, respectively. CONCLUSION This study demonstrates that the proposed new method has potential to help improve the sensitivity of lung nodule detection in future clinical practice.