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Loss-of-function ferroportin disease: novel mechanistic insights and unanswered questions

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Ferroportin, a 571 amino acid cation transporter encoded by the SLC40A1 gene, is the only known human cellular iron exporter and primarily expressed in the basolateral membrane of duodenal enterocytes,… Click to show full abstract

Ferroportin, a 571 amino acid cation transporter encoded by the SLC40A1 gene, is the only known human cellular iron exporter and primarily expressed in the basolateral membrane of duodenal enterocytes, macrophages, and hepatocytes.[1][1],[2][2] By regulating ferroportin-mediated iron export in these

Keywords: novel mechanistic; loss function; function ferroportin; ferroportin disease; mechanistic insights; disease novel

Journal Title: Haematologica
Year Published: 2018

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