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A tale of two genes: a new connection between NIPBL and NPM1 in acute myeloid leukemia

Acute myeloid leukemia (AML), the most common acute leukemia in adults, is defined by few somatic mutations in myeloid stem cells which drive abnormal proliferation and inhibit normal differentiation.[1][1] The… Click to show full abstract

Acute myeloid leukemia (AML), the most common acute leukemia in adults, is defined by few somatic mutations in myeloid stem cells which drive abnormal proliferation and inhibit normal differentiation.[1][1] The overall survival rate of adults with AML remains low despite current front-line induction

Keywords: genes new; tale two; myeloid leukemia; acute myeloid; two genes

Journal Title: Haematologica
Year Published: 2019

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