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Blood transcriptome and clonal T-cell correlates of response and non-response to eltrombopag therapy in a cohort of patients with chronic immune thrombocytopenia

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Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet count caused by accelerated platelet destruction and/or impaired platelet production. Chronic ITP is defined as ITP lasting for… Click to show full abstract

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet count caused by accelerated platelet destruction and/or impaired platelet production. Chronic ITP is defined as ITP lasting for more than 12 months.[1][1] T-cell abnormalities are implicated in ITP pathogenesis.

Keywords: transcriptome clonal; response; blood transcriptome; immune thrombocytopenia; cell

Journal Title: Haematologica
Year Published: 2019

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