LAUSR

https://jkms.org Cancer is the major cause of death in children and adolescents.1 According to the 2015 Korea Central Cancer Registry data, 1,353 children and adolescents (< 18 years) were diagnosed with cancer.2 Solid tumor comprises almost half of the cancer cases, with brain tumor being the most common tumor type.2 Solid tumors in children and adolescents are different from those of adults in clinical features and diversity of cellular origins.3 In adults, cancer rates tend to increase rapidly with increasing age. However, incidence pattern of childhood solid tumor follows an age-specific pattern.1 In early childhood, embryonal type solid tumors are common, such as retinoblastoma, neuroblastoma, hepatoblastoma, Wilms tumor, and medulloblastoma.1 In adolescents, solid tumors often arise from bone and soft tissues (osteosarcoma, Ewing sarcoma), germ cells (germ cell tumor) and epithelial cells (thyroid carcinoma).1