LAUSR

The euglycemic–hyperinsulinemic clamp (EHC) is the gold standard for assessing insulin sensitivity in peripheral tissues. 1 However, simpler metrics are needed to assess insulin resistance (IR). The metabolic score for the IR (METS-IR) index is a new metric for measuring IR that is simple, reliable, and reproducible. 1,2 Although Lee et al . 3 applied this score to Koreans, I would like to address some points regarding the associations between nonalcoholic fatty liver disease (NAFLD) and METS-IR. . The the outpatient diabetes of a in Mexico City. the 68 had type 2 diabetes mellitus (DM) and 57 did not. The subjects with DM were included if their glycated hemoglobin concentration was < 8%, they did not take insulin, and they were treated with only metformin. The of patients used to develop this score too small. the composition of the discovery population was heterogeneous. No precise definition of the METS-IR discovery population recruited provided. the factors in the METS-IR score reflect IR, the question is, whether an appropriate patient population recruited to develop the METS-IR.