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Changes in functional brain networks during epileptogenesis in a rodent model of temporal lobe epilepsy

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scanner. Usual preprocessing of fMRI and diffusion images and also parcellation to 90 regions (AAL template) were performed using FSL and ExploreDTI. FC and SC matrices were calculated based on… Click to show full abstract

scanner. Usual preprocessing of fMRI and diffusion images and also parcellation to 90 regions (AAL template) were performed using FSL and ExploreDTI. FC and SC matrices were calculated based on time series correlation and number of deterministic tractography streamlines, respectively. After vectorization and concatenation of FC and SC matrices, ICA was applied. To find reproducible components and reliable connectivity, RAICAR (Ranking and averaging independent component analysis by reproducibility) [2] and bootstrap resampling were performed. Reliable connectivity was selected by applying threshold at value corresponding to the 96% confidence interval. Results: We selected the 3 components which best overlapped with well-known functional subnetworks. Fig. 1 shows the functional and structural parts of components in red and blue, respectively. According to Fig. 1.a (red part), brain functional connectivity of the visual system is captured in the first component. The second functional network includes regions in medial prefrontal cortex, anterior cingulate cortex, precuneus etc., which can be interpreted as Default Mode Network (Fig. 1b). Also, functional connectivity in right parietal-frontal part of the brain may encode the right attentional/ executive network (Fig. 1c). The corresponding structural networks of functional parts are illustrated as well.

Keywords: functional brain; connectivity; changes functional; brain networks; networks epileptogenesis; brain

Journal Title: Frontiers in Neuroscience
Year Published: 2017

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