Fluorescence imaging in the second near infrared window (NIR-II, 1,000–1,700 nm) has been widely used in cancer diagnosis and treatment due to its high spatial resolution and deep tissue penetration… Click to show full abstract
Fluorescence imaging in the second near infrared window (NIR-II, 1,000–1,700 nm) has been widely used in cancer diagnosis and treatment due to its high spatial resolution and deep tissue penetration depths. In this work, recent advances in rare-earth-doped nanoparticles (RENPs)—a novel kind of NIR-II nanoprobes—are presented. The main focus of this study is on the modification of RENPs and their applications in NIR-II in vitro and in vivo imaging and cancer theranostics. Finally, the perspectives and challenges of NIR-II RENPs are discussed.
               
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