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C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope… Click to show full abstract
C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions are demonstrated in good to excellent conversions to furnish C (sp3)–N bonds on DNA. This DNA-compatible transformation has strong potentials for the application into DNA-encoded library synthesis.
Keywords:
dna;
dna conjugated;
chemistry;
hydroamination;
aryl alkenes;
conjugated aryl
Journal Title: Frontiers in Chemistry
Year Published: 2022
Link to full text (if available)
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Journal Title: Frontiers in Chemistry
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!