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In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against Botrytis cinereal (B. cinereal), Botryosphaeria dothidea (B. dothidea), and Phomopsis… Click to show full abstract
In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against Botrytis cinereal (B. cinereal), Botryosphaeria dothidea (B. dothidea), and Phomopsis sp. were determined using the poison plate technique. Biological test results showed that compound 6h revealed lower EC50 values (25.9 and 50.8 μg/ml) on Phompsis sp. than those of pyrimethanil (32.1 and 62.8 μg/ml).
Keywords:
antifungal activity;
derivatives bearing;
pyrimidine derivatives;
bearing thiadiazole;
thiadiazole skeleton;
novel pyrimidine
Journal Title: Frontiers in Chemistry
Year Published: 2022
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Journal Title: Frontiers in Chemistry
Year Published: 2022
Link to full text (if available)
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recommendations!