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Binary and ternary complexes of epinephrine with alginate and biologically and environmentally relevant metal cations

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The speciation of epinephrine (Eph −) in the presence of alginate (Alg 2-) and two biological and environmental relevant metal cations (Cu2+, UO2 2+) was investigated at T = 298.15K,… Click to show full abstract

The speciation of epinephrine (Eph −) in the presence of alginate (Alg 2-) and two biological and environmental relevant metal cations (Cu2+, UO2 2+) was investigated at T = 298.15K, I = 0.15–1.00 mol dm−3 in NaCl(aq). The formation of binary and ternary complexes was evaluated and, since epinephrine can behave as a zwitterion, the Eph −/Alg 2- interaction was studied by means of DOSY NMR. The dependence of the equilibrium constants on ionic strength was studied using an extended Debye-Hückel type equation and the SIT approach. The effect of temperature was investigated by means of isoperibolic titration calorimetry: the entropic contribution was the driving force for the Cu2+/Eph − complexes formation. The sequestering ability of Eph − and Alg 2- on Cu2+, evaluated by the pL0.5 calculation, increased with pH and ionic strength. The determination of pM parameter showed that Eph − had a higher Cu2+ affinity with respect to Alg 2-. The formation of Eph −/Alg 2- species was also investigated by UV-Vis spectrophotometry and 1H NMR measurements. The ternary Cu2+/Eph −/Alg 2- and Cu2+/UO2 2+/Eph − interactions were also studied. The “extra-stability” calculated for the mixed ternary species confirmed that their formation was thermodynamically favorable.

Keywords: cu2; relevant metal; metal cations; eph; binary ternary; ternary complexes

Journal Title: Frontiers in Chemistry
Year Published: 2023

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