LAUSR

Tissues undergo constant remodeling to maintain architecture during growth, in normal physiology and in response to disease. Interactions of the host with both commensals and pathogens, which include bacteria, viruses, fungi, and parasites, may affect not only immune responses due to recognition of pathogen associated molecular patterns (PAMPS), but also tissue remodeling including for example through the generation of neo-epitopes and damage-associated molecular patterns (DAMPS). Roles for the microbiome, viriome, fungi, as well as pathogenic bacteria and parasites, in both homeostasis and in host-pathogen interactions, is a topic of considerable interest regarding effects relating to chronic disease, cancer, dysbiosis, the gut-brain axis, host metabolism, drug metabolism, and zoonotic disease.