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Among the controversial issues surrounding combination T4/T3 therapy for hypothyroidism is the choice of the best biochemical parameter by which to monitor therapy. This article explores the potential use of… Click to show full abstract
Among the controversial issues surrounding combination T4/T3 therapy for hypothyroidism is the choice of the best biochemical parameter by which to monitor therapy. This article explores the potential use of reverse T3 (rT3) for this role. Unsubstantiated claims in layman websites have suggested that measurement of rT3 could serve as a useful guide for monitoring combined T4 and T3 replacement therapy. A brief review of aspects of the generation of rT3 from the peripheral metabolism of T4 may place into context the possible utility of rT3 for this role.
Journal Title: Frontiers in Endocrinology
Year Published: 2019
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