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Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective

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Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune… Click to show full abstract

Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.

Keywords: forward tolerance; inducing cellular; tolerance inducing; cellular therapies; ways forward

Journal Title: Frontiers in Immunology
Year Published: 2019

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