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The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, “mini-guts” derived… Click to show full abstract
The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, “mini-guts” derived from small intestinal crypt stem cells, and show that the intracellular MHC-II peptide-pathway is intact and functional in IECs. Our approach enables human enteroids to be used for novel in vitro studies into IEC MHC-II regulation and function during health and disease.
Keywords:
mhc gut;
mhc;
enteroids model;
model mhc;
intestinal enteroids;
human intestinal
Journal Title: Frontiers in Immunology
Year Published: 2019
Link to full text (if available)
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Journal Title: Frontiers in Immunology
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!