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Localized Intra-Cavitary Therapy to Drive Systemic Anti-Tumor Immunity

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Metastasis to the pleural and peritoneal cavities is a common terminal pathway for a wide variety of cancers. This article explores how these unique environments both promote aggressive tumor behavior… Click to show full abstract

Metastasis to the pleural and peritoneal cavities is a common terminal pathway for a wide variety of cancers. This article explores how these unique environments both promote aggressive tumor behavior and suppresses anti-tumor immunity, and ways in which local delivery of protein therapeutics can leverage the contained nature of these spaces to a therapeutic advantage, achieving high intra-cavital concentrations while minimizing systemic toxicity.

Keywords: tumor; localized intra; intra cavitary; anti tumor; tumor immunity

Journal Title: Frontiers in Immunology
Year Published: 2022

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