LAUSR

Keloid is an abnormal healing process of the wound, which is often secondary to the traumatic site, surgical incision, and even the needle path (1–3). Due to its rapid proliferation and growth rate, the keloid often protrudes from the skin and extends beyond the wound edge (4). This makes keloid a nasty disease that seriously affects their daily life and psychology (5). Histologically, the keloid is characterized by significant overformation of collagen fibers (6). It is worth mentioning that the immune microenvironment, previously thought to play an important role in tumors, is also believed to be involved in the formation and development of keloid in recent years (7). Multiple types of immune cells are speculated to constitute the chronic inflammatory background of keloid, and the inflammatory factors are involved in the activation and maintenance of keloid growth pathways (8). However, the keloid’s immune microenvironment is not well understood. In recent years, advances in bioinformatics techniques have made it possible to explore keloid genomics, proteomics, and the immune microenvironment in depth. In our previous paper “SingleCell Sequencing Analysis and Weighted Co-Expression Network Analysis Based on Public Databases Identified That TNC Is a Novel Biomarker for Keloid” which was published on 22 December 2021 in Frontiers in Immunology, the genomics of keloid was explored to a certain extent and tenascin-c(TNC) was identified as a robust marker of keloid by single-cell sequencing analysis and WGCNA (9). This article was commented by Xia et al. on Apr 04, 2022 (10). We are pleased to see that Xia et al. have added co-expression analysis, enrichment analysis, and correlation analysis of epithelial mesenchymal transformation(EMT)of TNC in keloid in that commentary article (10).