LAUSR

Neuroglial involvement comprises: (i) concerted actions in coordination with cells of the oligodendrocytic lineage and the neurovascular unit, (ii) reactivity when challenged by viral infection with COVID-19, resulting in CNS inflammation and changes in brain circuits associated with neuropsychiatric or neurological disorders, (iii) outcomes when the nervous tissue challenged with COVID-19 infection further has to deal with psychological stress, pollution, dietary imbalance, trauma, injury, and aging, and (iv) consequences of social isolation and psychological stress, in combination COVID-19 infection. The knowledge into the COVID-19-associated changes in non-neuronal cells is expected to contribute to the development of better-targeted therapies to preserve, improve or restore learning and memory, cognitive flexibility, stress resilience, sleep, metabolic fitness, and adaptation, among other essential CNS functions. [...]Yan et al. present data revealing an increased expression of receptors for SARS-CoV-2 in the prefrontal cortex of male, but not female mice exposed to chronic unpredictable stress.