LAUSR

Physiologically based neural field theory of the corticothalamic system is used to calculate the responses evoked by trains of auditory stimuli that correspond to different cortical locations via the tonotopic map. The results are shown to account for standard and deviant evoked responses to frequent and rare stimuli, respectively, in the auditory oddball paradigms widely used in human cognitive studies, and the so-called mismatch negativity between them. It also reproduces a wide range of other effects and variants, including the mechanism by which a change in standard responses relative to deviants can develop through adaptation, different responses when two deviants are presented in a row or a standard is presented after two deviants, relaxation of standard responses back to deviant form after a stimulus-free period, and more complex sequences. Some cases are identified in which adaptation does not account for the whole difference between standard and deviant responses. The results thus provide a systematic means to determine how much of the response is due to adaptation in the system comprising the primary auditory cortex and medial geniculate nucleus, and how much requires involvement of higher-level processing.