LAUSR

Zhang et al. investigated the efficacy of subthalamic nucleus deep brain stimulation (STN-DBS) in treating both motor and depressive symptoms in PD patients with treatment-resistant depression (PD-TRD). The results indicated that STN-DBS significantly improved motor and depressive symptoms, reduced the need for antiparkinsonian and antidepressant medications, and enhanced daily living activities and health-related quality of life after 1 year of treatment. Moreover, the study revealed widespread abnormalities in cerebral regional glucose metabolism in PD-TRD patients, which were partially recovered following STN-DBS treatment. These findings support the potential of STN-DBS as a promising treatment option for managing motor and depressive symptoms in PD-TRD patients.