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subthalamic nucleus, globus pallidus externa, and SNc. They simulated the molecular pathways involved in cell death of SNc neurons in terms of detailed chemical kinetics. The authors showed that energy… Click to show full abstract
subthalamic nucleus, globus pallidus externa, and SNc. They simulated the molecular pathways involved in cell death of SNc neurons in terms of detailed chemical kinetics. The authors showed that energy deficiencies occurring at cellular and network levels could precipitate the excitotoxic loss of SNc neurons in PD. Therapeutic effects of neuroprotective interventions were simulated.
Keywords:
modeling neurogenerative;
neurogenerative disorders;
brain modeling;
editorial brain;
snc
Journal Title: Frontiers in Neuroinformatics
Year Published: 2022
Link to full text (if available)
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Journal Title: Frontiers in Neuroinformatics
Year Published: 2022
Link to full text (if available)
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recommendations!