LAUSR

Purpose The study is conducted to identify the best corpus callosum (CC) sub-region that corresponds to highest callosal tissue alteration occurred due to Parkinsonism. In this regard the efficacy of local binary pattern (LBP) based texture analysis (TA) of CC is performed to quantify the changes in topographical distribution of callosal fiber connected to different regions of cortex. The extent of highest texture alteration in CC is used for differential diagnosis. Materials and Methods Study included subjects with Parkinson’s disease (PD) (n = 20), and atypical Parkinsonian disorders – multiple system atrophy (MSA) (n = 20), Progressive supranuclear palsy (PSP) (n = 20), and healthy controls (n = 20). For each subject, we have automated the ROI extraction within mid-sagittal CC, followed by LBP TA. Two-class support vector machine (SVM) classification for each disorder as against HC is performed using extracted LBP features like energy and entropy. Correct classification ratio (CCR) is computed as the fraction of correctly classified ROIs at each of the CC sub-regions based on well-known Witelson and Hofer schemes. Based on CCR values, the “Scatter Index (SI)” is proposed to capture how localized (closer to 0) or scattered (closer to 1) the textural changes are among the CC sub-regions, across all subjects per class. The CCR values are further utilized to classify the disease groups. Results Highest alteration of texture is observed in mid-body of CC. The consistency of this finding is quantified using SI for all subjects in a specific class that results more localized textural changes in PSP (15%) and MSA (25%), in comparison to PD (47%). Classification among disease groups results maximum classification accuracy of 90% in classifying PSP from PD-NC. Conclusion Our result demonstrates the efficacy of proposed methodology in analyzing tissue alteration in MRI of Parkinsonian disorders and thus has potential to become valuable tool in computer aided differential diagnosis.